Association of Long Term Abstinence with Normal Metabotropic Glutamate Receptor-5 Binding
نویسندگان
چکیده
Division of Molecular Psychiatry, Translational Research Center, University Hospital of Psychiatry, University of Bern, 3000 Bern 60, Switzerland PET Center, Division of Nuclear Medicine, University Hospital, 8091 Zurich, Switzerland Center for Radiopharmaceutical Science of ETH, PSI, and USZ, Department of Chemistry and Applied Biosciences of ETH, 8093 Zurich, Switzerland Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4002 Basel, Switzerland
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P6: Metabotropic Glutamate Receptor-Dependent Role in the Formation of Long-Term Potentiation
Long-term potentiation (LTP) is a reflection of synaptic plasticity that induced by specific patterns of synaptic activity and has an important role in learning and memory. The first clue of the potential role of glutamate receptors in LTP was in 1991 with the observation that the mGluR agonists 1-amino-1, 3-cyclopentanedicarboxylic acid (ACPD), increased LTP. Studies have shown that ACPD induc...
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Introduction: (S)- 3,5-Dihydroxyphenylglycine (DHPG) is an agonist for group I metabotropic glutamate receptors. DHPG-induced synaptic depression of excitatory synapses on hippocampal pyramidal neurons is well known model for synaptic plasticity studies. The aim of the present study was to examine the effects of DHPG superfusion on excitatory synapses on pyramidal and fast-spiking GABAergic cel...
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Background Cocaine addiction continues to be a major heath concern, and despite public health intervention there is a lack of efficient pharmacological treatment options. A newly identified potential target are the group I metabotropic glutamate receptors, with allosteric modulators showing particular promise. Methods We evaluated the capacity of group I metabotropic glutamate receptors to in...
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Class I metabotropic glutamate receptors (mGluRs) have been postulated to play a role in synaptic plasticity. To test the involvement of one member of this class, we have recently generated mutant mice that express no mGluR5 but normal levels of other glutamate receptors. The CNS revealed normal development of gross anatomical features. To examine synaptic functions we measured evoked field EPS...
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